The Covid-19 pandemic not only brought negative impacts on the health of people and businesses, but also changed habits of consumers and business methods. During the Covid-19 period, people became heavily dependent on Internet, such as online working, online learning, online shopping, etc. On the enterprises’ side, due to social distancing measures, businesses are compulsory to allow employees work from home, organize online meetings, do online marketing, increase sales online, etc. Therefore, Covid-19 not only brings negative impact on business activities but also brings pressure for businesses to accelerate digital transformation process. This is undoubtedly the time for businesses to realize the superiority of digital economy and the urgent requirement of digital transformation process. Digital transformation will help Vietnamese enterprises, especially MSMEs, find a more flexible business model, reduce costs, as well as optimize resources to overcome difficulties and recover after the Covid-19 pandemic. Although belong to the field of technology, the success or failure of digital transformation is not mainly dependent on technology. It mostly depends on political determination and national economic institutions. Therefore, the Government needs to create a system of modern economic institutions, with laws and skills to create an ecosystem for e-commerce and digital economy. It is the responsibility of businesses to renew their model, establish a governance model based on digital technology, towards innovative, sustainable and inclusive development goals. Digital transformation success stories show that the pioneers in digital transformation are those who are willing to change, willing to abandon traditional business models to establish new models, reinvent the supply chains and decision-making processes, eliminate the cumbersome, intermediaries stages. Organizational reform based on creative culture will be the first step toward digital economy. To accelerate digital transformation process, following the instructions of Prime Minister, VCCI is cooperating with relevant ministries and associations to implement supporting programs to promote digital transformation for businesses. VCCI has also chosen the theme of “digital transformation” for the most important events for business community in ASEAN 2020: Summit on Business and Investment (ASEAN BIS) and Viet Nam Business Summit (VBS). Specifically, these summit’ themes are “Digital, Sustainable and Inclusive ASEAN” and “Digital Viet Nam, Proactive Adaptation and Sustainable Development”. Digital transformation is an arduous journey, requiring high determination and courage. I want to quote General Vo Nguyen Giap for the journey of digital transformation in Viet Nam today: “Fast and then faster, bold and then bolder”. Only that way can Vietnamese enterprises emerge. The digital economy will be an opportunity for Vietnamese enterprises to re-navigate and change themselves in the world economy.